Publications

2019
	Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M *Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability* Mol Cell. 2018 Dec 24. pii: S1097-2765(18)31006-2. PubMed Full Text Article
2018
	Altmeyer M *Cells take a break when they are TIARed* EMBO Rep. 2018 Dec 11. pii: e47403. doi: 10.15252/embr.201847403. PubMed Full Text Article
	Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M *Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication* PNAS published ahead of print November 9, 2018 https://doi.org/10.1073/pnas.1809592115 PubMed Full Text Article
	Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D’Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA *CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress* Mol Cell. 2018 Nov 1;72(3):568-582.e6. PubMed Full Text Article
	Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M *Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance* Nat Commun. 2018 Jul 11;9(1):2678. PubMed Full Text Article Editors’ Highlights UZH Press Release EurekAlert
	Lezaja A, Altmeyer M *High Content Imaging für Multidimensionale Zellanalysen* BIOspektrum. 03/2018 Full Text Article English Author Version
	Altmeyer M *The memory remains* Aging (Albany NY). 2018 Mar 29. doi: 10.18632/aging.101408. PubMed Full Text Article
2017
	Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B *Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability* Sci Rep. 2017 Nov 8;7(1):15050. PubMed Full Text Article
	Lezaja A, Altmeyer M *Inherited DNA lesions determine G1 duration in the next cell cycle* Cell Cycle. 2017 Oct 5:0. doi: 10.1080/15384101.2017.1383578. PubMed Full Text Article News & Views by Strauss and Bartek
	Michelena J, Altmeyer M *Cell Cycle Resolved Measurements of Poly(ADP-Ribose) Formation and DNA Damage Signaling by Quantitative Image-Based Cytometry* Methods Mol Biol. 2017;1608:57-68. PubMed Full Text Article Complete Book
	Pellegrino S, Michelena J, Teloni F, Imhof R, Altmeyer M *Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin* Cell Reports 19, 1819–1831, 2017 PubMed Full Text Article
2016
	Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J *A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis* Developmental Cell 39, 740–755, December 19, 2016 PubMed Full Text Article
	Mangerich A, Altmeyer M *Identifying ADP-ribosylation targets by chemical genetics* Translational Cancer Research. 2016 doi: 10.21037/tcr.2016.11.06. Full Text Article Comment on: Gibson et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science 2016;353:45-50.
	Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C *53BP1 fosters fidelity of homology-directed DNA repair* Nat Struct Mol Biol. 2016 Jun 27. doi: 10.1038/nsmb.3251. PubMed Full Text Article Highlighted in More end resection is not merrier. Nat Struct Mol Biol. 2016 Aug 3;23(8):699-701. Received the cover image of the August 2016 issue of Nat Struct Mol Biol.
	Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO *PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation* Nucleic Acids Res. 2016 May 19. pii: gkw442. PubMed Full Text Article
	Pellegrino S, Altmeyer M *Interplay between ubiquitin, SUMO and poly(ADP-ribose) in the cellular response to genotoxic stress* Front. Genet., 19 April 2016 \| http://dx.doi.org/10.3389/fgene.2016.00063 PubMed Full Text Article

	Aguzzi A, Altmeyer M *Phase Separation: Linking Cellular Compartmentalization to Disease* Trends in Cell Biol. 2016 DOI: http://dx.doi.org/10.1016/j.tcb.2016.03.004 PubMed Full Text Article Featured article in the Special Issue: 25 Years of Trends in Cell Biology
	Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells Nature Comm. 2016 Feb 15. doi:10.1038/ncomms10660 PubMed Full Text Article
	Teloni F, Altmeyer M *Readers of poly(ADP-ribose): designed to be fit for purpose* Nucleic Acids Res. 2016 Feb 18;44(3):993-1006. PubMed Full Text Article
2015
	Lukas J, Altmeyer M *A lncRNA to repair DNA* EMBO Rep. 2015 Nov;16(11):1413-4. PubMed Full Text Article Comment on: Sharma V, et al. EMBO Rep. 2015 Sep 27. pii: e201540437.
	Altmeyer M, Neelsen, KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grofte M, Rask MB, Streicher W, Jungmichel S, Nielsen ML, Lukas J *Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)* Nature Comm. 2015 Aug 19;6:8088 PubMed Full Text Article Highlighted in PAR and the organization of the DNA damage response. Nat Struct Mol Biol. 2015 Sep 3;22(9):655. Covered by UZH News Covered by Vetsuisse News
2014
	Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage Nat Cell Biol. 2014 Aug;16(8):792-803 PubMed Full Text Article
2013
	Altmeyer M, Lukas J Guarding against collateral damage during chromatin transactions Cell 2013;153(7):1431-4 PubMed Full Text Article
	Altmeyer M, Lukas J To spread or not to spread–chromatin modifications in response to DNA damage Curr Opin Genet Dev 2013;23(2):156-65 PubMed Full Text Article
	Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling Mol Cell 2013;52(2):206-20 PubMed Full Text Article Highlighted in SAFB1 Regulates the Chromatin Response to DNA Damage. Cancer Discovery 2013;3
	Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses Mol Cell 2013;52(2):272-85 PubMed Full Text Article Received the cover image of Mol Cell. 2013 Oct 24;52(2).
	Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J ATR prohibits replication catastrophe by preventing global exhaustion of RPA Cell 2013;155(5):1088-103 PubMed Full Text Article Highlighted in Naked Replication Forks Break apRPArt. Cell 2013;155(5):979:980 Highlighted in Exhaustion of RPA Leads to Replication Catastrophe. Cancer Discovery 2014;4:16
2012
	Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes Cell 2012;150(4):697-709 PubMed Full Text Article Highlighted in DNA damage response: Restricting repair. Nat Rev Mol Cell Biol 2012;13(10):601 Highlighted in New ligases join the ubiquitylation cascade in repair. Nat Cell Biol 2012;14:990 Highlighted in TRIP12 and UBR5 Prevent Ubiquitin Spreading at Damaged Loci. Cancer Discovery 2012;2
	Altmeyer M *Addicted to PAR? A closer look at PARP inhibitor sensitivity* Cell Cycle. 2012 Nov 1;11(21):3916 PubMed Full Text Article Comment on: Oplustilova L, et al. Cell Cycle. 2012 Oct 15;11(20):3837-50.
2010
	Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding Cell 2010;142(6):943-53 PubMed Full Text Article Highlighted in Circadian rhythms: PARP1 feeds into clocks. Nat Rev Mol Cell Biol 2010;11(11):754-5 Highlighted in PARP around the clock. Cell 2010;142(6):841-3
	Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia Cancer Res. 2010 Jul 15;70(14):5912-22 PubMed Full Text Article Highlighted in: Issues in Cancer Epidemiology and Research: 2011 Edition. ISBN: 978-1-4649-6353-7
	Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO PARP1 ADP-ribosylates lysine residues of the core histone tails Nucleic Acids Res. 2010 Oct;38(19):6350-62. PubMed Full Text Article Highlighted as top 5% Featured Article by Nucleic Acids Res.
	Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation Infect Immun. 2010 Aug;78(8):3420-31. PubMed Full Text Article
2009
	Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites Nucleic Acids Res 2009;37(11):3723-38 PubMed Full Text Article
	Altmeyer M, Hottiger MO Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging Aging (Albany NY). 2009 May 20;1(5):458-69 PubMed Full Text Article
	Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation Nat Struct Mol Biol. 2009 Sep;16(9):923-9 PubMed Full Text Article Highlighted in Kraus WL. New functions for an ancient domain. Nat Struct Mol Biol. 2009 Sep;16(9):904-7.
	Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function FASEB J. 2009 Nov;23(11):3978-89 PubMed Full Text Article
2008
	Haenni SS, Altmeyer M, Hassa PO, Valovka T, Fey M, Hottiger MO Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS BMC Cell Biol. 2008 Jul 21;9:39 PubMed Full Text Article
	Haenni SS, Hassa PO, Altmeyer M, Fey M, Imhof R, Hottiger MO Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation Int J Biochem Cell Biol. 2008;40(10):2274-83. PubMed Full Text Article
2007
	Fahrer J, Kranaster R, Altmeyer M, Marx A, Bürkle A *Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length* Nucleic Acids Res. 2007;35(21):e143. PubMed Full Text Article

Publications

2019

Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability Mol Cell. 2018 Dec 24. pii: S1097-2765(18)31006-2.

2018

Altmeyer M Cells take a break when they are TIARed EMBO Rep. 2018 Dec 11. pii: e47403. doi: 10.15252/embr.201847403.

Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication PNAS published ahead of print November 9, 2018 https://doi.org/10.1073/pnas.1809592115

Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D’Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress Mol Cell. 2018 Nov 1;72(3):568-582.e6.

Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance Nat Commun. 2018 Jul 11;9(1):2678.

Lezaja A, Altmeyer M High Content Imaging für Multidimensionale Zellanalysen BIOspektrum. 03/2018

Altmeyer M The memory remains Aging (Albany NY). 2018 Mar 29. doi: 10.18632/aging.101408.

2017

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability Sci Rep. 2017 Nov 8;7(1):15050.

Lezaja A, Altmeyer M Inherited DNA lesions determine G1 duration in the next cell cycle Cell Cycle. 2017 Oct 5:0. doi: 10.1080/15384101.2017.1383578.

Michelena J, Altmeyer M Cell Cycle Resolved Measurements of Poly(ADP-Ribose) Formation and DNA Damage Signaling by Quantitative Image-Based Cytometry Methods Mol Biol. 2017;1608:57-68.

Pellegrino S, Michelena J, Teloni F, Imhof R, Altmeyer M Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin Cell Reports 19, 1819–1831, 2017

2016

Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis Developmental Cell 39, 740–755, December 19, 2016

Mangerich A, Altmeyer M Identifying ADP-ribosylation targets by chemical genetics Translational Cancer Research. 2016 doi: 10.21037/tcr.2016.11.06.

Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C 53BP1 fosters fidelity of homology-directed DNA repair Nat Struct Mol Biol. 2016 Jun 27. doi: 10.1038/nsmb.3251.

Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation Nucleic Acids Res. 2016 May 19. pii: gkw442.

Pellegrino S, Altmeyer M Interplay between ubiquitin, SUMO and poly(ADP-ribose) in the cellular response to genotoxic stress Front. Genet., 19 April 2016 | http://dx.doi.org/10.3389/fgene.2016.00063

Aguzzi A, Altmeyer M Phase Separation: Linking Cellular Compartmentalization to Disease Trends in Cell Biol. 2016 DOI: http://dx.doi.org/10.1016/j.tcb.2016.03.004

Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells Nature Comm. 2016 Feb 15. doi:10.1038/ncomms10660

Teloni F, Altmeyer M Readers of poly(ADP-ribose): designed to be fit for purpose Nucleic Acids Res. 2016 Feb 18;44(3):993-1006.

2015

Lukas J, Altmeyer M A lncRNA to repair DNA EMBO Rep. 2015 Nov;16(11):1413-4.

Altmeyer M, Neelsen, KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grofte M, Rask MB, Streicher W, Jungmichel S, Nielsen ML, Lukas J Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose) Nature Comm. 2015 Aug 19;6:8088

2014

Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage Nat Cell Biol. 2014 Aug;16(8):792-803

2013

Altmeyer M, Lukas J Guarding against collateral damage during chromatin transactions Cell 2013;153(7):1431-4

Altmeyer M, Lukas J To spread or not to spread–chromatin modifications in response to DNA damage Curr Opin Genet Dev 2013;23(2):156-65

Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling Mol Cell 2013;52(2):206-20

Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses Mol Cell 2013;52(2):272-85

Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J ATR prohibits replication catastrophe by preventing global exhaustion of RPA Cell 2013;155(5):1088-103

2012

Altmeyer M Addicted to PAR? A closer look at PARP inhibitor sensitivity Cell Cycle. 2012 Nov 1;11(21):3916

2010

Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding Cell 2010;142(6):943-53

Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia Cancer Res. 2010 Jul 15;70(14):5912-22

Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO PARP1 ADP-ribosylates lysine residues of the core histone tails Nucleic Acids Res. 2010 Oct;38(19):6350-62.

Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation Infect Immun. 2010 Aug;78(8):3420-31.

2009

Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites Nucleic Acids Res 2009;37(11):3723-38

Altmeyer M, Hottiger MO Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging Aging (Albany NY). 2009 May 20;1(5):458-69

Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation Nat Struct Mol Biol. 2009 Sep;16(9):923-9

Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function FASEB J. 2009 Nov;23(11):3978-89

2008

Haenni SS, Altmeyer M, Hassa PO, Valovka T, Fey M, Hottiger MO Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS BMC Cell Biol. 2008 Jul 21;9:39

Haenni SS, Hassa PO, Altmeyer M, Fey M, Imhof R, Hottiger MO Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation Int J Biochem Cell Biol. 2008;40(10):2274-83.

2007

Fahrer J, Kranaster R, Altmeyer M, Marx A, Bürkle A Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length Nucleic Acids Res. 2007;35(21):e143.

Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M
Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability
Mol Cell. 2018 Dec 24. pii: S1097-2765(18)31006-2.

Altmeyer M
Cells take a break when they are TIARed
EMBO Rep. 2018 Dec 11. pii: e47403. doi: 10.15252/embr.201847403.

Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M
Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication
PNAS published ahead of print November 9, 2018 https://doi.org/10.1073/pnas.1809592115

Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D’Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
Mol Cell. 2018 Nov 1;72(3):568-582.e6.

Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M
Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
Nat Commun. 2018 Jul 11;9(1):2678.

Lezaja A, Altmeyer M
High Content Imaging für Multidimensionale Zellanalysen
BIOspektrum. 03/2018

Altmeyer M
The memory remains
Aging (Albany NY). 2018 Mar 29. doi: 10.18632/aging.101408.

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Sci Rep. 2017 Nov 8;7(1):15050.

Lezaja A, Altmeyer M
Inherited DNA lesions determine G1 duration in the next cell cycle
Cell Cycle. 2017 Oct 5:0. doi: 10.1080/15384101.2017.1383578.

Michelena J, Altmeyer M
Cell Cycle Resolved Measurements of Poly(ADP-Ribose) Formation and DNA Damage Signaling by Quantitative Image-Based Cytometry
Methods Mol Biol. 2017;1608:57-68.

Pellegrino S, Michelena J, Teloni F, Imhof R, Altmeyer M
Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin
Cell Reports 19, 1819–1831, 2017

Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J
A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis
Developmental Cell 39, 740–755, December 19, 2016

Mangerich A, Altmeyer M
Identifying ADP-ribosylation targets by chemical genetics
Translational Cancer Research. 2016 doi: 10.21037/tcr.2016.11.06.

Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C
53BP1 fosters fidelity of homology-directed DNA repair
Nat Struct Mol Biol. 2016 Jun 27. doi: 10.1038/nsmb.3251.

Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO
PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation
Nucleic Acids Res. 2016 May 19. pii: gkw442.

Pellegrino S, Altmeyer M
Interplay between ubiquitin, SUMO and poly(ADP-ribose) in the cellular response to genotoxic stress
Front. Genet., 19 April 2016 | http://dx.doi.org/10.3389/fgene.2016.00063

Aguzzi A, Altmeyer M
Phase Separation: Linking Cellular Compartmentalization to Disease
Trends in Cell Biol. 2016 DOI: http://dx.doi.org/10.1016/j.tcb.2016.03.004

Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
Nature Comm. 2016 Feb 15. doi:10.1038/ncomms10660

Teloni F, Altmeyer M
Readers of poly(ADP-ribose): designed to be fit for purpose
Nucleic Acids Res. 2016 Feb 18;44(3):993-1006.

Lukas J, Altmeyer M
A lncRNA to repair DNA
EMBO Rep. 2015 Nov;16(11):1413-4.

Altmeyer M, Neelsen, KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grofte M, Rask MB, Streicher W, Jungmichel S, Nielsen ML, Lukas J
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Nature Comm. 2015 Aug 19;6:8088

Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Nat Cell Biol. 2014 Aug;16(8):792-803

Altmeyer M, Lukas J
Guarding against collateral damage during chromatin transactions
Cell 2013;153(7):1431-4

Altmeyer M, Lukas J
To spread or not to spread–chromatin modifications in response to DNA damage
Curr Opin Genet Dev 2013;23(2):156-65

Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J
The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling
Mol Cell 2013;52(2):206-20

Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML
Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses
Mol Cell 2013;52(2):272-85

Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
Cell 2013;155(5):1088-103

Altmeyer M
Addicted to PAR? A closer look at PARP inhibitor sensitivity
Cell Cycle. 2012 Nov 1;11(21):3916

Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Cell 2010;142(6):943-53

Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A
Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia
Cancer Res. 2010 Jul 15;70(14):5912-22

Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO
PARP1 ADP-ribosylates lysine residues of the core histone tails
Nucleic Acids Res. 2010 Oct;38(19):6350-62.

Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO
Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation
Infect Immun. 2010 Aug;78(8):3420-31.

Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO
Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
Nucleic Acids Res 2009;37(11):3723-38

Altmeyer M, Hottiger MO
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
Aging (Albany NY). 2009 May 20;1(5):458-69

Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Nat Struct Mol Biol. 2009 Sep;16(9):923-9

Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO
Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function
FASEB J. 2009 Nov;23(11):3978-89

Haenni SS, Altmeyer M, Hassa PO, Valovka T, Fey M, Hottiger MO
Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS
BMC Cell Biol. 2008 Jul 21;9:39

Haenni SS, Hassa PO, Altmeyer M, Fey M, Imhof R, Hottiger MO
Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation
Int J Biochem Cell Biol. 2008;40(10):2274-83.

Fahrer J, Kranaster R, Altmeyer M, Marx A, Bürkle A
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length
Nucleic Acids Res. 2007;35(21):e143.