Two theses presentations, one for a M.Sc. and one for a Ph.D., given as webinars by Michaela and Aleksandra, respectively, mark the successful ending of their research in our lab. Well done and all the best for the steps ahead!
In a recent publication we identified replication stress-induced ssDNA lesions in G1 cells. They are found at telomeres in ALT-positive cancer cells and show signs of post-mitotic DNA synthesis (post-MiDAS).
We have openings for a postdoctoral researcher and a PhD student to join our lab. If you are interested in cancer biology and genome integrity maintenance and have a liking for quantitative cell biology, please get in touch.
June 2021
Fragile genomic regions undergo mitotic DNA synthesis (MiDAS). Aleksandra found evidence for post-mitotic DNA synthesis (post-MiDAS). Post-MiDAS occurs at telomeres, particularly in ALT-positive cancer cells, and is amplified by replication stress. Published in Nature Communications.
Lezaja et al., Nat Commun. 2021 Jun 22;12(1):3827.
November 2020
From a close collaboration with the lab of Haico van Attikum, and with great help from the labs of Sébastien Huet, Alfred Vertegaal, Jessica Downs and Martijn Luijsterburg, the chromatin remodeler CHD7 emerged as an early responder to DNA damage to regulate chromatin dynamics around DNA break sites and initiate repair. Finally out in Nature Communications.
Rother, Pellegrino et al., Nat Commun. 2020 Nov 13;11(1):5775.
August 2020
We found that the ubiquitin E3 ligase TRIP12, through its PAR-binding WWE domain, targets PARP1 for proteasomal degradation, affecting PARP functions and PARP inhibitor efficiency. Congratulations to Marco and big thanks to our collaborators Qingyao Huang and Michael Baudis for their help. Published in Cell Reports.
Gatti et al., Cell Rep. 2020 Aug 4;32(5):107985.
July 2019
Spearheaded by Matteo Berti from Massimo Lopes’ group and Federico Teloni from our lab, our collaborative study on RAD51 and replication fork reversal is finally out in Nature Communications.
Berti, Teloni et al., Nat Commun. 2020 Jul 15;11(1):3531.
