Publications
2023
Spegg V, Altmeyer M.
Genome maintenance meets mechanobiology.
Chromosoma. 2023 Aug 15. doi: 10.1007/s00412-023-00807-5.
Nina Schmolka, Ino D Karemaker, Richard Cardoso da Silva, Davide C Recchia, Vincent Spegg, Jahnavi Bhaskaran, Michael Teske, Nathalie P de Wagenaar, Matthias Altmeyer, Tuncay Baubec
Dissecting the roles of MBD2 isoforms and domains in regulating NuRD complex function during cellular differentiation
Nat Commun. 2023 Jun 29;14(1):3848. doi: 10.1038/s41467-023-39551-w.
Aswini Krishnan, Vincent Spegg, Susanne Dettwiler, Peter Schraml, Holger Moch, Konstantin Dedes, Zsuzsanna Varga, Matthias Altmeyer
Analysis of the PARP1, ADP-Ribosylation, and TRIP12 Triad With Markers of Patient Outcome in Human Breast Cancer
Mod Pathol. 2023 Mar 27;36(7):100167. doi: 10.1016/j.modpat.2023.100167. Online ahead of print.
Vincent Spegg, Andreas Panagopoulos, Merula Stout, Aswini Krishnan, Giordano Reginato, Ralph Imhof, Bernd Roschitzki, Petr Cejka, Matthias Altmeyer
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres
Nat Struct Mol Biol. 2023 Apr;30(4):451-462. doi: 10.1038/s41594-023-00932-w. Epub 2023 Mar 9.
2022
Thorsten Mosler, H Irem Baymaz, Justus F Gräf, Ivan Mikicic, Georges Blattner, Edward Bartlett, Matthias Ostermaier, Rossana Piccinno, Jiwen Yang, Andrea Voigt, Marco Gatti, Stefania Pellegrino, Matthias Altmeyer, Katja Luck, Ivan Ahel, Vassilis Roukos, Petra Beli
PARP1 proximity proteomics reveals interaction partners at stressed replication forks
Nucleic Acids Res. 2022 Nov 11;50(20):11600-11618. doi: 10.1093/nar/gkac948.
Singh JK, Noordermeer SM, Jimenez-Sainz J, Maranon DG, Altmeyer M
Editorial: Protecting the code: DNA double-strand break repair pathway choice
Front Genet. 2022 Aug 12;13:993889.
Groelly FJ, Dagg RA, Petropoulos M, Rossetti GG, Prasad B, Panagopoulos A, Paulsen T, Karamichali A, Jones SE, Ochs F, Dionellis VS, Puig Lombardi E, Miossec MJ, Lockstone H, Legub e G, Blackford AN, Altmeyer M, Halazonetis TD, Tarsounas M
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells
Mol Cell. 2022 Aug 17:S1097-2765(22)00707-9.
Bolck HA, Przetocka S, Meier R, von Aesch C, Zurfluh C, Hänggi K, Spegg V, Altmeyer M, Stebler M, Nørrelykke SF, Horvath P, Sartori AA, Porro A ✉️
RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor
Cells. 2022 Feb 12;11(4):643.
Balbo Pogliano C, Ceppi I, Giovannini S, Petroulaki V, Palmer N, Uliana F, Gatti M, Kasaciunaite K, Freire R, Seidel R, Altmeyer M, Cejka P ✉️, Matos J ✉️
The CDK1-TOPBP1-PLK1 axis regulates the Bloom’s syndrome helicase BLM to suppress crossover recombination in somatic cells
Science Advances. 2022 Feb 4;8(5):eabk0221.
2021
Yilmaz D, Furst A, Meaburn K, Lezaja A, Wen Y, Altmeyer M, Reina-San-Martin B, Soutoglou E ✉️
Activation of homologous recombination in G1 preserves centromeric integrity
Nature. 2021 Dec;600(7890):748-753.
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When the RAP (80) fades out, you can hear BRCA1 RING
EMBO Rep. 2021 Nov 2:e54116.
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Biomolecular condensates at sites of DNA damage: More than just a phase
DNA Repair (Amst). 2021 Oct;106:103179.
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FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats
Sci Adv. 2021 Jul 30;7(31):eabf7906.
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ADP-ribosyltransferases, an update on function and nomenclature
FEBS J. 2021 Jul 29. doi: 10.1111/febs.16142.
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RPA shields inherited DNA lesions for post-mitotic DNA synthesis
Nat Commun. 2021 Jun 22;12(1):3827.
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TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs
Mol Cell. 2021 Jun 17;81(12):2583-2595.e6.
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AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
Mol Cell. 2021 Jun 17;81(12):2596-2610.e7.
Michelena J, Pellegrino S, Spegg V, Altmeyer M ✉️
Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells
Life Sci Alliance. 2021 Apr 2;4(6):e202101023.
Roeschert I, Poon E, Henssen AG, Garcia HD, Gatti M, Giansanti C, Jamin Y, Ade CP, Gallant P, Schülein-Völk C, Beli P, Richards M, Rosenfeldt M, Altmeyer M, Anderson J, Eggert A, Dobbelstein M, Bayliss R, Chesler L, Büchel G, Eilers M ✉️
Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma
Nat Cancer. 2021 Mar;2(3):312-326.
Hopp AK, Teloni F, Bisceglie L, Gondrand C, Raith F, Nowak K, Muskalla L, Howald A, Pedrioli PGA, Johnsson K, Altmeyer M, Pedrioli DML, Hottiger MO ✉️
Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation
Mol Cell. 2021 Jan 21;81(2):340-354.e5.
Lezaja A, Altmeyer M ✉️
Dealing with DNA lesions: When one cell cycle is not enough
Curr Opin Cell Biol. 2020 Dec 10;70:27-36.
Panagopoulos A, Altmeyer M ✉️
The Hammer and the Dance of Cell Cycle Control
Trends Biochem Sci. 2021 Apr;46(4):301-314.
2020
Rother MB*, Pellegrino S*, Smith R, Gatti M, Meisenberg C, Wiegant WW, Luijsterburg MS, Imhof R, Downs JA, Vertegaal ACO, Huet S, Altmeyer M ✉️, van Attikum H ✉️
CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks
Nature Commun. 2020 Nov 13;11(1):5775.* equal contribution
Walser F, Mulder MPC, Bragantini B, Burger S, Gubser T, Gatti M, Botuyan MV, Villa A, Altmeyer M, Neri D, Ovaa H, Mer G, Penengo L ✉️
Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response
Mol Cell. 2020 Sep 29;S1097-2765(20)30647-X.
Gatti M, Imhof R, Huang Q, Baudis M, Altmeyer M ✉️
The ubiquitin ligase TRIP12 limits PARP1 trapping and constrains PARP inhibitor efficiency
Cell Rep. 2020 Aug 4;32(5):107985.
Berti M*, Teloni F*, Mijic S, Ursich S, Fuchs J, Palumbieri MD, Krietsch J, Schmid JA, Garcin EB, Gon S, Modesti M, Altmeyer M ✉️, Lopes M ✉️
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart
Nat Commun. 2020 Jul 15;11(1):3531. * equal contribution
Buljan M, Ciuffa R, van Drogen A, Vichalkovski A, Mehnert M, Rosenberger G, Lee S, Varjosalo M, Pernas LE, Spegg V, Snijder B, Aebersold R ✉️, Gstaiger M ✉️
Kinase interaction network expands functional and disease roles of human kinases
Mol Cell. 2020 Aug 6;79(3):504-520.e9.
Simon AK, Kummer S, Wild S, Lezaja A, Teloni F, Jozwiakowski SK, Altmeyer M, Gari K ✉️
The iron-sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation
Life Sci Alliance. 2020 Feb 18;3(3):e201900547.
2019
Michelena J, Gatti M, Teloni F, Imhof R, Altmeyer M ✉️
Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions
J Cell Biol. 2019 Sep 2;218(9):2865-2875.
Kilic S, Lezaja A, Gatti M, Bianco E, Michelena J, Imhof R, Altmeyer M ✉️
Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments
EMBO J. 2019 Aug 15;38(16):e101379.
PubMed
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News & Views by Piccinno, Minneker & Roukos
Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M ✉️
Efficient pre-mRNA cleavage prevents replication-stress-associated genome instability
Mol Cell. 2019 Feb 21;73(4):670-683.e12.
Altmeyer M ✉️
Cells take a break when they are TIARed
EMBO Rep. 2019 Jan;20(1):e47403.
2018
Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M ✉️
Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication
Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11311-E11320.
Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D’Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA ✉️
CtIP-mediated fork protection synergizes with BRCA1 to suppress genomic instability upon DNA replication stress
Mol Cell. 2018 Nov 1;72(3):568-582.e6.
Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M ✉️
Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
Nat Commun. 2018 Jul 11;9(1):2678.
PubMed
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Editors’ Highlights
UZH Press Release
EurekAlert
Nature Protocol Exchange
Lezaja A, Altmeyer M ✉️
High Content Imaging für Multidimensionale Zellanalysen
BIOspektrum. 03/2018
Altmeyer M ✉️
The memory remains
Aging (Albany NY). 2018 Mar 29. doi: 10.18632/aging.101408.
2017
Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B ✉️
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Sci Rep. 2017 Nov 8;7(1):15050.
Lezaja A, Altmeyer M ✉️
Inherited DNA lesions determine G1 duration in the next cell cycle
Cell Cycle. 2017 Oct 5:0. doi: 10.1080/15384101.2017.1383578.
Michelena J, Altmeyer M ✉️
Cell cycle resolved measurements of poly(ADP-ribose) formation and DNA damage signaling by quantitative image-based cytometry
Methods Mol Biol. 2017;1608:57-68.
Pellegrino S*, Michelena J*, Teloni F, Imhof R, Altmeyer M ✉️
Replication-coupled dilution of H4K20me2 guides 53BP1 to pre-replicative chromatin
Cell Rep. 2017 May 30;19(9):1819-1831. * equal contribution
2016
Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J ✉️
A mechanism for controlled breakage of under-replicated chromosomes during mitosis
Developmental Cell 39, 740–755, December 19, 2016
Mangerich A ✉️, Altmeyer M ✉️
Identifying ADP-ribosylation targets by chemical genetics
Translational Cancer Research. 2016 doi: 10.21037/tcr.2016.11.06.
Full Text Article
Comment on: Gibson et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science 2016;353:45-50.
Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J ✉️, Lukas C
53BP1 fosters fidelity of homology-directed DNA repair
Nat Struct Mol Biol. 2016 Aug;23(8):714-21.
PubMed
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Highlighted in More end resection is not merrier. Nat Struct Mol Biol. 2016 Aug 3;23(8):699-701.
Received the cover image of the August 2016 issue of Nat Struct Mol Biol.
Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO ✉️
PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation
Nucleic Acids Res. 2016 Sep 19;44(16):7630-45
Pellegrino S, Altmeyer M ✉️
Interplay between ubiquitin, SUMO and poly(ADP-ribose) in the cellular response to genotoxic stress
Front Genet. 2016 Apr 19;7:63
Aguzzi A, Altmeyer M ✉️
Phase separation: Linking cellular compartmentalization to disease
Trends Cell Biol. 2016 Jul;26(7):547-558
PubMed
Full Text Article
Featured article in the Special Issue: 25 Years of Trends in Cell Biology
Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M ✉️
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
Nat Commun. 2016 Feb 15;7:10660
Teloni F, Altmeyer M ✉️
Readers of poly(ADP-ribose): designed to be fit for purpose
Nucleic Acids Res. 2016 Feb 18;44(3):993-1006.
2015
Lukas J , Altmeyer M ✉️
A lncRNA to repair DNA
EMBO Rep. 2015 Nov;16(11):1413-4.
PubMed
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Comment on: Sharma V, et al. EMBO Rep. 2015 Sep 27. pii: e201540437.
Altmeyer M ✉️, Neelsen, KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grofte M, Rask M, Streicher W, Jungmichel S, Nielsen ML, Lukas J ✉️
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Nature Comm. 2015 Aug 19;6:8088
PubMed
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Highlighted in PAR and the organization of the DNA damage response. Nat Struct Mol Biol. 2015 Sep 3;22(9):655.
Covered by UZH News
Covered by Vetsuisse News
2014
Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J ✉️, Stucki M ✉️
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Nat Cell Biol. 2014 Aug;16(8):792-803
2013
Altmeyer M ✉️, Lukas J ✉️
Guarding against collateral damage during chromatin transactions
Cell 2013;153(7):1431-4
Altmeyer M ✉️, Lukas J ✉️
To spread or not to spread–chromatin modifications in response to DNA damage
Curr Opin Genet Dev 2013;23(2):156-65
Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J ✉️
The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling
Mol Cell 2013;52(2):206-20
PubMed
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Highlighted in SAFB1 Regulates the Chromatin Response to DNA Damage. Cancer Discovery 2013;3
Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML ✉️
Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses
Mol Cell 2013;52(2):272-85
PubMed
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Received the cover image of Mol Cell. 2013 Oct 24;52(2).
Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J ✉️
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
Cell 2013;155(5):1088-103
PubMed
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Highlighted in Naked Replication Forks Break apRPArt. Cell 2013;155(5):979:980
Highlighted in Exhaustion of RPA Leads to Replication Catastrophe. Cancer Discovery 2014;4:16
2012
Gudjonsson T*, Altmeyer M*, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J ✉️, Lukas C
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
Cell 2012;150(4):697-709. * equal contribution
PubMed
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Highlighted in DNA damage response: Restricting repair. Nat Rev Mol Cell Biol 2012;13(10):601
Highlighted in New ligases join the ubiquitylation cascade in repair. Nat Cell Biol 2012;14:990
Highlighted in TRIP12 and UBR5 Prevent Ubiquitin Spreading at Damaged Loci. Cancer Discovery 2012;2
Altmeyer M ✉️
Addicted to PAR? A closer look at PARP inhibitor sensitivity
Cell Cycle. 2012 Nov 1;11(21):3916
PubMed
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Comment on: Oplustilova L, et al. Cell Cycle. 2012 Oct 15;11(20):3837-50.
2010
Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U ✉️
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Cell 2010;142(6):943-53
PubMed
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Highlighted in Circadian rhythms: PARP1 feeds into clocks. Nat Rev Mol Cell Biol 2010;11(11):754-5
Highlighted in PARP around the clock. Cell 2010;142(6):841-3
Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A ✉️
Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia
Cancer Res. 2010 Jul 15;70(14):5912-22
PubMed
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Highlighted in: Issues in Cancer Epidemiology and Research: 2011 Edition. ISBN: 978-1-4649-6353-7
Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO ✉️
PARP1 ADP-ribosylates lysine residues of the core histone tails
Nucleic Acids Res. 2010 Oct;38(19):6350-62.
PubMed
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Highlighted as top 5% Featured Article by Nucleic Acids Res.
Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO ✉️
Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation
Infect Immun. 2010 Aug;78(8):3420-31.
2009
Matthias Altmeyer, Simon Messner, Paul O Hassa, Monika Fey, Michael O Hottiger
Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
Nucleic Acids Res. 2009 Jun; 37(11): 3723–3738.
Altmeyer M, Hottiger MO ✉️
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
Aging (Albany NY). 2009 May 20;1(5):458-69
Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG ✉️
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Nat Struct Mol Biol. 2009 Sep;16(9):923-9
PubMed
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Highlighted in Kraus WL. New functions for an ancient domain. Nat Struct Mol Biol. 2009 Sep;16(9):904-7.
Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO ✉️
Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function
FASEB J. 2009 Nov;23(11):3978-89
2008
Haenni SS*, Altmeyer M*, Hassa PO, Valovka T, Fey M, Hottiger MO ✉️
Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS
BMC Cell Biol. 2008 Jul 21;9:39. * equal contribution
