As part of an active scientific community that studies the DNA damage response (DDR) and its impact on cancer and aging, research in the lab of Matthias Altmeyer is aimed at elucidating cellular mechanisms of genome integrity maintenance and their deregulation in human disease. Here you can explore who we are and what we do. Welcome!
Phase separation of DNA repair compartments
Our newest research article has just been published in EMBO Journal and is currently among the most read papers there. We show that DNA repair compartments marked by 53BP1 have liquid-like properties and provide insights into specificity and function of phase separation.
In our recent publication in Molecular Cell we uncover that the pre-mRNA cleavage factor WDR33 protects cells from replication stress. We propose that pre-mRNA cleavage is needed to release nascent mRNAs from the genome and thereby prevent topological problems during replication.
We are always looking for motivated postdoctoral researchers and/or MSc/PhD students to join our lab. If you are interested in chromatin dynamics and genome stability and have a liking for quantitative cell biology, please take a look at our open positions.
Replication stress is a hallmark of many cancers. In an article published in the February 2019 issue of Molecular Cell (Volume 73, Issue 4, p641-858) we identify the pre-mRNA cleavage factor WDR33 as regulator of replication stress resilience and demonstrate that, when WDR33 function is impaired, unreleased nascent transcripts and genomic loci re-localize toward the nuclear periphery, where they cause replication stress and DNA damage.
Our paper on PARP inhibitor toxicity is published in Nature Communications! Have a look how high-content imaging reveals the earliest cellular responses to PARP inhibition and unravels the sequence of events from PARP trapping to DNA damage, cell cycle arrest and cell death. Here you can access the complete article and browse through the Editors’ Highlights, or read the UZH/EurekAlert public releases.
Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
Lab research featured in UZH Magazin and in the Annual Report 2017
Research of the group brought to life by Roland Fischer and photographer Marc Latzel for UZH Magazin 01/2018 (UZH News). Download the full article or the complete magazine (in German). Read the English translation here.