How do cells keep a stable genome? What is the cellular toolkit to repair damaged DNA? How do cells choose which tool to use? And how can quantitative cell biology help tackle these questions? Fresh minds were ready for some brainwork during an inspiring one-day lab retreat.
Read how the DNA damage response utilizes replication-coupled dilution of a histone mark, H4K20me2, to guide BRCA1’s antagonist 53BP1 to pre-replicative chromatin and thereby facilitate the choice between NHEJ and HR during S-phase progression.
Motivated applications from postdoctoral researchers with a strong interest in genome stability or chromatin biology and willing to apply for fellowships are always encouraged. PhD students are recruited through the Life Science Zurich Graduate School.
Current Research Highlights
