As part of an active scientific community that studies the DNA damage response (DDR) and its impact on cancer and aging, research in the lab of Matthias Altmeyer is aimed at elucidating cellular mechanisms of genome integrity maintenance and their deregulation in human disease. Here you can explore who we are and what we do. Welcome!

DSB Repair Pathway Choice During S-phase

Poster Prize to lab member Federico Teloni

Congratulations to Federico, who won a prize for his poster at the 4th German-French DNA Repair Meeting in Cologne, Germany. Federico presented his project on a convergent multidimensional screen to identify cancer-relevant genes with roles in replication stress resilience. Well done!

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DSB Repair Pathway Choice During S-phase

DSB Repair Pathway Choice During S-phase

Read how the DNA damage response utilizes replication-coupled dilution of a histone mark, H4K20me2, to guide BRCA1’s antagonist 53BP1 to pre-replicative chromatin and thereby facilitate the choice between NHEJ and HR during S-phase progression.

Publications

Postdoctoral Candidates and PhD Students

Postdoctoral Candidates and PhD Students

Motivated applications from postdoctoral researchers with a strong interest in genome stability or chromatin biology and willing to apply for fellowships are always encouraged. PhD students are recruited through the Life Science Zurich Graduate School.

Current Openings

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