Publications

2019

Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M
Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability
Mol Cell. 2018 Dec 24. pii: S1097-2765(18)31006-2.

PubMed
Full Text Article


2018

Altmeyer M
Cells take a break when they are TIARed
EMBO Rep. 2018 Dec 11. pii: e47403. doi: 10.15252/embr.201847403.

PubMed
Full Text Article

Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M
Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication
PNAS published ahead of print November 9, 2018 https://doi.org/10.1073/pnas.1809592115 

PubMed
Full Text Article

Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D’Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
Mol Cell. 2018 Nov 1;72(3):568-582.e6.

PubMed
Full Text Article

Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M
Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
Nat Commun. 2018 Jul 11;9(1):2678. 

PubMed
Full Text Article
Editors’ Highlights
UZH Press Release
EurekAlert

Lezaja A, Altmeyer M
High Content Imaging für Multidimensionale Zellanalysen
BIOspektrum. 03/2018

Full Text Article
English Author Version

Altmeyer M
The memory remains
Aging (Albany NY). 2018 Mar 29. doi: 10.18632/aging.101408. 

PubMed
Full Text Article


2017

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Sci Rep. 2017 Nov 8;7(1):15050.

PubMed
Full Text Article

Lezaja A, Altmeyer M
Inherited DNA lesions determine G1 duration in the next cell cycle
Cell Cycle. 2017 Oct 5:0. doi: 10.1080/15384101.2017.1383578.

PubMed
Full Text Article
News & Views by Strauss and Bartek

Michelena J, Altmeyer M
Cell Cycle Resolved Measurements of Poly(ADP-Ribose) Formation and DNA Damage Signaling by Quantitative Image-Based Cytometry
Methods Mol Biol. 2017;1608:57-68.

PubMed
Full Text Article
Complete Book


2016

Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J
A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis
Developmental Cell 39, 740–755, December 19, 2016

PubMed
Full Text Article

Mangerich A, Altmeyer M
Identifying ADP-ribosylation targets by chemical genetics
Translational Cancer Research. 2016 doi: 10.21037/tcr.2016.11.06.

Full Text Article
Comment on: Gibson et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science 2016;353:45-50.

Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C
53BP1 fosters fidelity of homology-directed DNA repair
Nat Struct Mol Biol. 2016 Jun 27. doi: 10.1038/nsmb.3251.

PubMed
Full Text Article
Highlighted in More end resection is not merrier. Nat Struct Mol Biol. 2016 Aug 3;23(8):699-701.
Received the cover image of the August 2016 issue of Nat Struct Mol Biol.

Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO
PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation
Nucleic Acids Res. 2016 May 19. pii: gkw442.

PubMed
Full Text Article

Pellegrino S, Altmeyer M
Interplay between ubiquitin, SUMO and poly(ADP-ribose) in the cellular response to genotoxic stress
Front. Genet., 19 April 2016 | http://dx.doi.org/10.3389/fgene.2016.00063

PubMed
Full Text Article

Aguzzi A, Altmeyer M
Phase Separation: Linking Cellular Compartmentalization to Disease
Trends in Cell Biol. 2016 DOI: http://dx.doi.org/10.1016/j.tcb.2016.03.004

PubMed
Full Text Article
Featured article in the Special Issue: 25 Years of Trends in Cell Biology

Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M
short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
Nature Comm. 2016 Feb 15. doi:10.1038/ncomms10660 

PubMed
Full Text Article

Teloni F, Altmeyer M
Readers of poly(ADP-ribose): designed to be fit for purpose
Nucleic Acids Res. 2016 Feb 18;44(3):993-1006.

PubMed
Full Text Article


2015

Lukas J, Altmeyer M
A lncRNA to repair DNA
EMBO Rep. 2015 Nov;16(11):1413-4.

PubMed
Full Text Article
Comment on: Sharma V, et al. EMBO Rep. 2015 Sep 27. pii: e201540437.

Altmeyer M, Neelsen, KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grofte M, Rask MB, Streicher W, Jungmichel S, Nielsen ML, Lukas J
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Nature Comm. 2015 Aug 19;6:8088

PubMed
Full Text Article
Highlighted in PAR and the organization of the DNA damage response. Nat Struct Mol Biol. 2015 Sep 3;22(9):655.
Covered by UZH News
Covered by Vetsuisse News


2014

Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Nat Cell Biol. 2014 Aug;16(8):792-803

PubMed
Full Text Article


2013

Altmeyer M, Lukas J
Guarding against collateral damage during chromatin transactions
Cell 2013;153(7):1431-4

PubMed
Full Text Article

Altmeyer M, Lukas J
To spread or not to spread–chromatin modifications in response to DNA damage
Curr Opin Genet Dev 2013;23(2):156-65

PubMed
Full Text Article

Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J
The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling
Mol Cell 2013;52(2):206-20

PubMed
Full Text Article
Highlighted in SAFB1 Regulates the Chromatin Response to DNA Damage. Cancer Discovery 2013;3

Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML
Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses
Mol Cell 2013;52(2):272-85

PubMed
Full Text Article
Received the cover image of Mol Cell. 2013 Oct 24;52(2).

Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
Cell 2013;155(5):1088-103

PubMed
Full Text Article
Highlighted in Naked Replication Forks Break apRPArt. Cell 2013;155(5):979:980
Highlighted in Exhaustion of RPA Leads to Replication Catastrophe. Cancer Discovery 2014;4:16


2012

Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
Cell 2012;150(4):697-709

PubMed
Full Text Article
Highlighted in DNA damage response: Restricting repair. Nat Rev Mol Cell Biol 2012;13(10):601
Highlighted in New ligases join the ubiquitylation cascade in repair. Nat Cell Biol 2012;14:990
Highlighted in TRIP12 and UBR5 Prevent Ubiquitin Spreading at Damaged Loci. Cancer Discovery 2012;2

Altmeyer M
Addicted to PAR? A closer look at PARP inhibitor sensitivity
Cell Cycle. 2012 Nov 1;11(21):3916

PubMed
Full Text Article
Comment on: Oplustilova L, et al. Cell Cycle. 2012 Oct 15;11(20):3837-50.


2010

Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Cell 2010;142(6):943-53

PubMed
Full Text Article
Highlighted in Circadian rhythms: PARP1 feeds into clocks. Nat Rev Mol Cell Biol 2010;11(11):754-5
Highlighted in PARP around the clock. Cell 2010;142(6):841-3

Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A
Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia
Cancer Res. 2010 Jul 15;70(14):5912-22

PubMed
Full Text Article
Highlighted in: Issues in Cancer Epidemiology and Research: 2011 Edition. ISBN: 978-1-4649-6353-7

Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO
PARP1 ADP-ribosylates lysine residues of the core histone tails
Nucleic Acids Res. 2010 Oct;38(19):6350-62.

PubMed
Full Text Article
Highlighted as top 5% Featured Article by Nucleic Acids Res.

PubMed
Full Text Article

Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO
Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation
Infect Immun. 2010 Aug;78(8):3420-31.

PubMed
Full Text Article


2009

Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO
PARP1 ADP-ribosylates lysine residues of the core histone tails
Nucleic Acids Res. 2010 Oct;38(19):6350-62.

PubMed
Full Text Article
Highlighted as top 5% Featured Article by Nucleic Acids Res.

Altmeyer M, Hottiger MO
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
Aging (Albany NY). 2009 May 20;1(5):458-69

PubMed
Full Text Article

Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Nat Struct Mol Biol. 2009 Sep;16(9):923-9

PubMed
Full Text Article
Highlighted in Kraus WL. New functions for an ancient domain. Nat Struct Mol Biol. 2009 Sep;16(9):904-7.

Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO
Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function
FASEB J. 2009 Nov;23(11):3978-89

PubMed
Full Text Article


2008

Haenni SS, Altmeyer M, Hassa PO, Valovka T, Fey M, Hottiger MO
Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS
BMC Cell Biol. 2008 Jul 21;9:39

PubMed
Full Text Article

Haenni SS, Hassa PO, Altmeyer M, Fey M, Imhof R, Hottiger MO
Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation
Int J Biochem Cell Biol. 2008;40(10):2274-83.

PubMed
Full Text Article


2007

Fahrer J, Kranaster R, Altmeyer M, Marx A, Bürkle A
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length
Nucleic Acids Res. 2007;35(21):e143.

PubMed
Full Text Article

UA-67564934-1